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- Oral cleft prevention program (OCPP)
- The primary prevention of birth defects: Multivitamins or folic acid?
- Facts about Cleft Lip and Cleft Palate
Oral cleft prevention program (OCPP)
Jump to navigation. Folic acid is a synthetic form of folate used in supplements and fortified staple foods like wheat and maize flour to reduce the occurrence of neural tube defects NTDs. These include spina bifida or cleft spine , where there is an opening in one or more of the bones vertebrae of the spinal column, and anencephaly where the head cephalic end of the neural tube fails to close. Supplementation with folic acid is internationally recommended to women from the moment they are trying to conceive until 12 weeks of pregnancy. Supplementation may also reduce other birth defects such as cleft lip, with or without cleft palate, and congenital cardiovascular defects. Recently, 5-methyl-tetrahydrofolate 5-MTHF has been proposed as an alternative to folic acid supplementation. This is because most dietary folate and folic acid are metabolised to 5-MTHF.
Metrics details. Oral clefts are one of the most common birth defects with significant medical, psychosocial, and economic ramifications. Oral clefts have a complex etiology with genetic and environmental risk factors. There are suggestive results for decreased risks of cleft occurrence and recurrence with folic acid supplements taken at preconception and during pregnancy with a stronger evidence for higher than lower doses in preventing recurrence. Yet previous studies have suffered from considerable design limitations particularly non-randomization into treatment. There is also well-documented effectiveness for folic acid in preventing neural tube defect occurrence at 0. Given the substantial burden of clefting on the individual and the family and the supportive data for the effectiveness of folic acid supplementation as well as its low cost, a randomized clinical trial of the effectiveness of high versus low dose folic acid for prevention of cleft recurrence is warranted.
Objectives : To determine the awareness amongst dental students, practitioners and maxillofacial surgeons the role of folic acid in the prevention of CLAP and its clinical use. Materials and Methods : Questionnaire based study involving a sample base of , comprising of dental students, practitioners and specialist maxillofacial surgeons. Results : hundred percent of the sample population were aware of CLAP disorders, of which 9. Conclusion : Educating healthcare providers and, in turn, the prospective parents on benefits folic acid would not only help in reducing the incidence of CLAP but also significantly influence the economics of the patients afflicted with CLAP disorders. Folic acid in cleft lip, alveolus and palate prevention: Awareness among dental professionals. Indian J Dent Res ;
The primary prevention of birth defects: Multivitamins or folic acid?
See the Latest Publications. Browse All Publications. Download PDF. Julie Garden-Robinson, Ph. Folic acid is a B vitamin the body needs for healthy cells and blood.
International Journal of Biological Sciences. Journal of Cancer. Journal of Genomics. Global reach, higher impact. Journal of Genomics - Submit manuscript now Int J Med Sci ; 1 1 Andrew E.
folate and gene polymorphisms in the metabolic pathway of folic acid as regards the occurrence of NSCL/P. We reviewed theoretical material that.
Facts about Cleft Lip and Cleft Palate
Chile [online]. ISSN Background : The effect of food fortification with folic acid on the incidence of lip-palate fissures FLP is under discussion. Aim : To calculate the rate of hospital discharges due to cleft lip and palate CLP and explore whether they decreased after the start of folic acid fortification in Chile. Material and Methods : The hospital discharge databases published by the Chilean Ministry of Health were analyzed.
Correspondence Address : Dr. Advanced Search. Users Online: Advanced Search Users Online: How to cite this article: Langer V.
A cleft lip is an opening or split in the upper lip that occurs when developing facial structures in an unborn baby don't close completely. Cleft lip may be unilateral or bilateral. A baby with a cleft lip may also experience a cleft in the roof of the mouth cleft palate. A cleft palate is an opening or split in the roof of the mouth that occurs when the tissue doesn't fuse together during development in the womb.
Why is folic acid important to health?
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