File Name: cytochrome p450 2e1 its role in disease and drug metabolism .zip
CYP2E1 enzyme is related to nonalcoholic steatohepatitis NASH due to its ability for reactive oxygen species production, which can be influenced by polymorphisms in the gene.
- Cytochrome P450 2E1 and its roles in disease
- Cytochrome P450 2E1: Its Role in Disease and Drug Metabolism
- The Role of CYP2E1 in the Drug Metabolism or Bioactivation in the Brain
Skip to main content Skip to table of contents. Advertisement Hide.
Cytochrome P450 2E1 and its roles in disease
Cytochromes Ps CYPs are terminal enzymes in CYP dependent monooxygenases, which constitute a superfamily of enzymes catalysing the metabolism of both endogenous and exogenous substances. One of their main tasks is to facilitate the excretion of these substances and eliminate their toxicities in most phase 1 reactions. Endogenous substrates of CYPs include steroids, bile acids, eicosanoids, cholesterol, vitamin D and neurotransmitters. Genetic polymorphisms of CYPs may affect the enzyme functions and have been reported to be associated with various diseases and adverse drug reactions among different populations. In addition, their significance in metabolism concerning ulcerative colitis in patients is also discussed showing a clear underestimation in genetic studies performed so far. Extrahepatic and extrarenal CYPs e. Polymorphisms discussed can result in dysregulation of these enzymes in favour of alternative pathways producing more reactive metabolites.
Cytochrome P450 2E1: Its Role in Disease and Drug Metabolism
Metrics details. The cytochrome P CYP enzymes are a class of heme-containing enzymes involved in phase I metabolism of a large number of xenobiotics. The CYP family member CYP2E1 metabolises many xenobiotics and pro-carcinogens, it is not just expressed in the liver but also in many other tissues such as the kidney, the lung, the brain, the gastrointestinal tract and the breast tissue. It is induced in several pathological conditions including cancer, obesity, and type II diabetes implying that this enzyme is implicated in other biological processes beyond its role in phase I metabolism. Despite the detailed description of the role of CYP2E1 in the liver, its functions in other tissues have not been extensively studied. In this study, we investigated the functional significance of CYP2E1 in breast carcinogenesis. The endoplasmic reticulum stress and the unfolded protein response UPR were detected by luciferase assays reflecting the splicing of mRNA encoding the X-box binding protein 1 XBP1 transcription factor and cell migration was evaluated using the scratch wound assay.
Cytochrome P 2E1: Its Role in Disease and Drug Metabolism. ISBN ; Digitally watermarked, DRM-free; Included format: PDF, EPUB.
The Role of CYP2E1 in the Drug Metabolism or Bioactivation in the Brain
Alcoholic steatohepatitis ASH —the inflammation of fatty liver—is caused by chronic alcohol consumption and represents one of the leading chronic liver diseases in Western Countries. Long-term alcohol abstinence reduces this probability and is the prerequisite for liver transplantation—the only effective therapy option at present. Elevated enzymatic activity of cytochrome P 2E1 CYP2E1 is known to be critically responsible for the development of ASH due to excessively high levels of reactive oxygen species ROS during metabolization of ethanol. In this study, we applied a rational drug design concept to develop drug candidates NCE including preclinical studies. A new class of drug candidates was generated successfully.
Rubio-Osornio, M. Calvillo-Velasco, J. Guevara, D.